After learning that their younger sibling escaped an earlier kidnapping attempt that also killed their parents, two estranged sisters must join forces to rescue her from a group of bloodthirsty vampires. Out for revenge and control of a vampirism vaccine, Thorn and his band of the undead soon learn that they messed with the wrong family.

Meredith, humaine artificielle désignée comme compagne de William, a été conçue pour se comporter comme sa défunte épouse. Cependant, une organisation tente de saboter sa programmation.